老年高血压病患者左心室肥厚与脑白质疏松症的关系

Association of left ventricular hypertrophy with leukoaraiosis in elderly patients with hypertension

目的 探讨老年高血压病患者左心室肥厚和脑白质疏松症 (LA)的关系。方法 13 8例老年高血压病患者 ,按有或无LA分为两组 ,并对其年龄、是否合并左心室肥厚、糖尿病、高胆固醇血症、吸烟史以及收缩压和舒张压水平、高血压病持续时间进行分析。结果 在单因素Logistic回归分析中 ,左心室肥厚、收缩压水平、高血压病持续时间及年龄均为LA的影响因素 ;在多因素条件Logistic回归分析中 ,左心室肥厚仍为LA的危险因素之一 (OR =2 .771,95 %CI值 1.2 60～6.0 94;P <0 .0 1)。结论 左心室肥厚为老年高血压病患者LA独立的危险因素。

Objective To investigate whether left ventricular hypertrophy(LVH) is a risk factor for leukoaraiosis(LA) in elderly persons with hypertension.Methods 138 hypertensive patients with or without LA were investigated.We analysed the clinical features such as the age, LVH, the duration of hypertention,systolic and diastolic blood pressure, diabetes mellitus, hypercholesterolemia and smoking.Results In the univariate analysis, the age, LVH, the duration of hypertention, systolic blood pressure were statistically significant risk factors of LA in elderly persons with hypertension.Multivariate analysis revealed that LVH was a significant risk factor when the age, the duration of hypertention, systolic blood pressure as covariates in a logistic model(OR=2.771;95%CI,1.260～6.049;P<0.01).Conclusion LVH is a risk factor for LA in elderly persons with hypertension.