氟伐他汀与普伐他汀治疗高脂血症疗效比较

Fluvastatin vs pravastatin in treating hyperlipidemia

目的 :观察并比较氟伐他汀与普伐他汀的降脂疗效。方法 :氟伐他汀组 4 1例 (男性 2 2例 ,女性 19例 ,年龄 6 0a±s 8a) ,应用氟伐他汀 2 0～ 4 0mg ,po ,qn× 4wk。普伐他汀组 35例 (男性 2 0例 ,女性 15例 ,年龄 6 0a± 6a) ,应用普伐他汀 10mg ,po ,qn× 4wk。结果 :氟伐他汀降低TC的总有效率 92 % ,普伐他汀为 70 % (P <0 .0 5) ;氟伐他汀降低TG及升高HDL C的总有效率为 6 1%和 6 1% ,与普伐他汀的 73%和 6 9%相似 (P >0 .0 5)。 2组的不良反应发生率为 2 0 % (8/41)和 2 0 % (7/35)。结论 :氟伐他汀是一种安全、有效的降脂药物 ,且降低TC作用优于普伐他汀。

AIM: To observe and compare the antihyperlipidemia efficacy of fluvastatin vs pravasatin. METHODS: Fluvastatin group( n =41,M 22, F 19; age 60 a± s 8 a) was treated with fluvastatin 20 40 mg, po , qn for 4 wk. Pravastatin group( n =35, M 20, F 15; age 60 a±6 a) was treated with pravastatin 10 mg, po , qn for 4 wk. RESULTS: The total effective rate of fluvastatin for reducing TC was 92 %, it was higher than that of pravastatin 70 %( P <0.05). The total effective rates of flavastatin for reducing TG and raising HDL C were 61 % and 61 %, were similar to that of pravastatin 73 % and 69 %( P >0.05). Adverse reactions occurred in 8 patients of fluvastatin(20 %) and in 7 patients of pravastatin(20 %), but were mild in both groups. CONCLUSION: Fluvastatin is a safe and effective antihyperlipidemic drug, and fluvastatin is more effective than pravastatin in decreasing total cholesterol.