胞磷胆碱治疗药源性锥外系副作用

Citicoline in treating neuroleptic-induced extrapyramidal side effect

目的 :探讨胞磷胆碱对药源性锥外系副作用 (EPS)的疗效。方法 :75例病人分为 2组。胞磷胆碱组 38例 (男性 2 5例 ,女性 13例 ,年龄 2 8a±s9a) ,用胞磷胆碱 0 .5g加入 5%葡萄糖注射液 50 0mL中iv ,gtt ,qd ;对照组 37例 (男性 2 3例 ,女性 14例 ,年龄 2 7a± 7a) ,用 5%葡萄糖注射液 50 0mL ,iv ,gtt ,qd ,疗程均 2wk。治疗期间禁用抗胆碱能等与EPS有关的药物。结果 :胞磷胆碱组和对照组总有效率分别为 92 %和 11% ,经Ridit分析 ,P <0 .0 5。胞磷胆碱组对震颤、肌强直、步态和肌张力障碍效果较好。治疗期间未出现副作用。结论 :胞磷胆碱对药源性EPS具有较好的治疗作用。

AIM:To study the effects of citicoline in treating neuroleptic-induced extrapyramidal side effect (EPS). METHODS:Seventy five patients were divided into two groups:citicoline group of 38 patients ( M25,F13;age 28 a± s 9 a) received citicoline injection 0.5 g.d 1 ,in 5 % glucose injection 500 mL,iv,drip,qd ,for 14 d and control group of 37 patients ( M23,F14;age 27 a±6 a) received 5 % glucose injection 500 mL,iv, drip, qd,for 14 d. RESULTS: The total efficacy of citicoline or control group was 92 % and 11 % ( P <0.05 ), respectively.The tremour, muscular rigidity, gait and muscle dystonia were better in citicoline group than in control group. No side effects were found. CONCLUSION: Citicoline is effective for neuroleptic-induced EPS.