甘草酸铵对慢性病毒性肝炎血清细胞外基质的影响

Affect of ammonium glycyrrhizinate on extracellular matrix of chronic viral hepatitis

目的 :为了探讨甘草酸铵 2种制剂对慢性病毒性肝炎病人血清细胞外基质 (ECM )的影响。方法 :70例病人随机分为甘草酸二铵组 4 1例 (年龄4 7a±s 13a)和甘草酸单铵组 2 9例 (年龄 4 8a± 12a) ,分别静脉滴注甘草酸二铵和甘草酸单铵每日 1次 ,30d后采用放免法检测病人血清ECM。结果 :甘草酸二铵组和甘草酸单铵组治疗后各项ECM值明显下降 (P <0 .0 1) ,而治疗后 2组ECM下降值间除板层素 (LN)差异无显著意义 (P >0 .0 5) ,其他各项差异均有显著或非常显著意义 (P <0 .0 5或P <0 .0 1)。结论 :甘草酸铵 2种制剂均可降低慢性病毒性肝炎病人的血清ECM ,具有一定的抗纤维化作用 ,尤以甘草酸二铵的作用更甚。

AIM:To study the affect of two kind preparations of ammonium glycyrrhizinate on serum extracellular matrix level of chronic viral hepatitis. METHODS: Seventy patients with chronic viral hepatitis were randomly divided into two groups. The first group of 41 patients (M36,F5;age 47a± s 13a) was treated with diammonium glycyrrhizinate 0.15 g, iv, gtt, qd×30 d. The second group of 29 patients (M23,F6; age 48a±12a) was treated with monoamonium glycyrrhizinate 0.2 g iv, gtt, qd×30 d. Serum ECM levels were assayed using RIA method. RESULTS: After treatment the serum ECM levels of both groups reduced remarkably and there was no differance in the reduction of serum ECM levels of the two groups except LN ( P <0.05, P <0.01). CONCLUSION: Both preparations of glycyzzhizinate have the efficacy to reduce serum ECM level of chronic viral hepatitis patients and play some role in anti hepatic fibrosis. Diammonium glycyrrhizinate is more potent than monoammonium glycyrrhizinate.