贝那普利对高血压病和冠心病左室舒张功能不全的影响

Influence of benazepril to left ventricular diastolic dysfunction in patients with hypertension and coronary heart disease

目的 :了解贝那普利对高血压病和冠心病左室舒张功能的影响。方法 :81例左室舒张功能不全病人 (高血压 4 5例 ,冠心病 36例 ;男性 56例 ,女性 2 5例 )应用贝那普利 10～ 2 0mg(冠心病在口服硝酸酯类药基础上加服贝那普利 5mg) ,po ,qd× 5mo ;用药前后用彩色多普勒超声心动图测定舒张早期最大峰值速度 (E峰 )、舒张晚期最大峰值速度 (A峰 )、E/A峰值速度比值及最快充盈率 (PFR)。结果 :治疗后比治疗前E峰、E/A比值、PFR均升高 ,而A峰降低 ,差别均有非常显著意义 (P <0 .0 1)。结论 :高血压病和冠心病病人服用贝那普利 5mo左右 ,对左室舒张功能不全有明显改善作用。

AIM: To understand the effects of benazepril in treating the diastolic function of the left ventricular in patients with hypertention and coronary heart diseases(CHD). METHODS: Forty five hypertension patients with the left ventricular diastolic dysfunction(LVDD) received benazepril 10-20 mg, po ,qd, for 5 mo. On the basis of receiving nitrates 36 CHD patients with LVDD added to receive benazepril 5 mg, po , qd, for 5 mo. Before and after the therapy, the utmost speed of the peak value at the left ventricular early diastole stage (E peak), the utmost speed of the peak value at the left ventricular late diastolic stage (A peak), the E/A ratio and peak filling rate (PFR) were determined by color Doppler echocardiography. RESULTS: After the therapy, the E peak, the E/A ratio and PFR were up higher than before the therapy, meanwhile the A peak dropped lower, there were significant difference respectively ( P < 0.01 ). CONCLUSION: The LVDD can be improved distinctly if the patients with hypertension and CHD take benazepril for 5 mo or so.