脑创宁对脑组织含水量和血脑屏障通透性影响

EFFECT OF NAOCHUANGNING ON CEREBRAL EDEMA AND PERMEABILITY OF BLOOD-BRAIN BARRIER

目的 :考察脑创宁对闭合性脑外伤小鼠脑水肿、血脑屏障通透性的作用。方法 :采用自由落体法复制闭合性脑外伤小鼠模型 ,测定脑组织含水量和伊文思蓝含量。结果 :脑创宁可明显减轻模型小鼠脑水肿程度 ,降低伊文思蓝含量 ,保护血脑屏障。结论

Objective:To research the effect of Naochuangning on cerebral edema and the permeability of blood brain barrier in closed cerebral trauma mice.Method:The freely falling object was used to simulate the animal models of closed cerebral trauma.The content of water and Evans blue of brain tissue were determined.Result:Naochuangning could obviously lessen the level of cerebral edema and cut down the content of Evans blue and protect the blood brain barrier.Conclusion:Naochuangning have protective effects on the brain tissue in closed cerebral trauma mice.