脾虚患者脂质过氧化和红细胞免疫功能关系

RELATIONSHIP BETWEEN LIPID PEROXIDATION AND RED BLOOD CELL IMMUNE FUNCTION IN PATIENTS WITH SPLEEN DEFICIENCY

目的 :探讨脾虚患者脂质过氧化对红细胞免疫功能的影响。方法 :采用红细胞酵母菌混合花环法和硫代巴比妥酸 (TBA)法检测脾虚患者红细胞膜C3b受体花环率 (RBC C3bRR)、血浆及红细胞膜丙二醛 (MDA)水平。结果 :脾虚患者RBC C3bRR和红细胞膜免疫复合物花环率 (RBC ICR)明显降低 ,血浆MDA和红细胞膜MDA明显升高 ;RBC C3bRR与血浆MDA、红细胞膜MDA呈负相关 ,其中红细胞膜MDA和RBC C3bRR关系更为密切。结论 :红细胞膜脂质过氧化损害对RBC

Objective:To explore the effect of lipid peroxidation on red blood cell immune function in patients with spleen deficiency.Method:By the methods of TBA and red blood cell yeast mixed flower circle,the RBC C 3b receptor rate,malonyldialdehyde(MDA) of plasma and erythrocyte membrane in patients with spleen deficiency were determined respectively.Result:The red blood cell C 3b receptor rate(RBC C 3bRR)and red blood cell immune compound(RBC IC) were lowered,but the MDA content in plasma and erythrocyte membrane were increased respectively.The relative analysis suggested that there were relationship between the RBC C 3bRR and MAD content in plasma and erythrocyte membrane.Conclusion:The lipid peroxidation lesion of red blood cell membrane had a bad effect on RBC C 3bRR.