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抗组胺新药特非那定(terfenadine)的药理和临床概况 被引量:1

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摘要 特非那定(terfenadine)是Carr等于1973年创制、美国Merrell制药公司于1981年首先上市的抗组胺新药,目前已在欧美各国广泛使用。其化学名称为:α-[4-(1,1—二甲基乙基)苯基]-4-(羟基二苯基甲基)—1—哌啶丁醇。结构式为: 该药在抗组胺类药中属于组胺H_1受体拮抗剂。所谓组胺H_1受体拮抗剂是能与组胺竞争效应细胞上的组胺H_1受体,使组胺不能同H_1受体结合,从而抑制其引起过敏反应的作用。
机构地区 湖北制药厂
出处 《湖北医药导报》 1991年第3期1-3,共3页
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  • 6Argekar AP, Shah SJ, Raj SV. Simultaneous determination of pseudoephidrine HC1 (PSE) and terfanidine (TER) from formulations by reversed-phase ion pair high-performance liquid chromatography (RP-HPLC)[J]. Drug Dev Ind Pharm, 1998,24(3) :219- 223.
  • 7Martens J. Deternination of the terfenadine metabolite azacyclonol in human serum using gas chromatographymass spectrometry [ J]. J Chromatogr B Biomed Appl, 1996,678 (2) : 349 - 353.
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  • 9Ghoneim M, Issa R, Tawfik A. Assay of terfenadine in pharmaceutical formulation and human plasma by adsorptive stripping voltammetry [ J ]. J Pharm Biomed Anal, 2001,26(4) :593 - 598.

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