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连锁分析血管紧张素转换酶基因插入/缺失多态性和血管紧张素原M235T基因多态性与肥厚型心肌病的关系 被引量：2

Linkage analysis of the association of genetic polymorphisms of angiotensin converting enzyme and angiotensinogen M235T with hypertrophic cardiomyopathy
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摘要 目的　连锁分析中国人群血管紧张素转换酶 (ACE)基因插入 /缺失多态性及血管紧张素原 (AGT)M2 3 5T基因多态性与肥厚型心肌病 (HCM)发病的关系。方法　对 63例HCM患者分别用PCR法检测ACE基因插入 /缺失和AGTM2 3 5T基因多态性。结果　HCM患者中ACEDD +AGTTT基因型的比数比高于单基因型 ,其心脏事件发生率高于其他基因型组合者和AGTTT型。结论　同时具有ACEDD +AGTTT基因型者 ,较单基因型发生HCM的风险率显著增高 ;同时具有ACEDD +AGTTT基因型的HCM患者发生心脏事件的危险更大。 Objective To evaluate the association of the genetic polymorphism of angiotensinogen (AGT) and angiotensin converting enzyme (ACE) with the risk of hypertrophic cardiomyopathy (HCM) in Chinese people. Methods Polymerase chain reaction (PCR) was carried out to detect the polymorphisms of ACE and AGT genes in 63 HCM patients. Results In HCM patients, the odds ratio (OR) estimated by linkage analysis of ACE-DD and AGT-TT genotypes was markedly higher when compared with that estimated separately from the ACE-DD or AGT-TT genotype. The risk of cardiac events was higher in HCM patients with both ACE-DD and AGT-TT genotypes than that in those with other combination of ACE and AGT genotypes and also higher than that in those with AGT-TT genotype only. Conclusions Combination of ACE-DD and AGT-TT genotypes may have synergistic effect on the risk of HCM in Chinese people. The risk of cardiac events was much higher in HCM patients with both ACE-DD and AGT-TT genotypes.
作者 杨荣 张馥敏 马文珠 谢勇 贾永平
机构地区 南京医科大学第一附属医院心内科
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2001年第4期231-234,共4页 Chinese Journal of Cardiology
关键词 肥厚型心肌病 血管紧张素原 连锁分析 基因多态性 Cardiomyopathy, hypertrophic Genes Angiotensinogen Peptidyl-Dipeptidase A
分类号 R542.2 [医药卫生—心血管疾病]
  • 相关文献

参考文献7

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共引文献2

同被引文献32

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中华心血管病杂志
2001年 第4期

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