菲立磁增强MRI在肝脏局灶性病变诊断中的价值

Evaluation of Feridex-enhanced MRI in the Diagnosis of Focal Hepatic Lesions

目的 评价菲立磁增强MRI在肝脏实性占位性病变诊断中的应用价值。材料与方法 对 2 1例怀疑有肝脏局灶性占位病变患者行MR平扫及菲立磁增强MRI检查。扫描序列包括频率选择脂肪抑制及非脂肪抑制HASTET2 WI、TrueFISPT2 WI、频率选择脂肪抑制FLASHT1WI。比较增强前后T2 WI及T2 WI病灶及肝脏的信噪比 (SNR)及对比噪声比 (CNR) ;观察增强前后病灶数量及形态 ;结合MR平扫及增强MRI表现进行定性诊断。结果 菲立磁增强T2 WI及T2 WI肝脏信号强度较平扫明显下降 ,病灶与肝脏的CNR较平扫明显提高 ,差异具有统计学意义。结论 菲立磁增强T2 WI及T2 WI可明显提高肝脏实性占位性病灶的检出率。菲立磁增强T1WI在肝脏局灶性病变的定性诊断中具有潜在价值 ,有待于进一步开发与研究。

Objective To evaluate Feridex (superparamagnetic iron oxide, SPIO) enhanced MRI in the diagnosis of hepatic focal solid lesions.Materials and Methods Plain and Feridex enhanced MRI were performed in 21 patients with suspected focal hepatic lesions. The enhanced MRI scanning started at 60min. After intravenous infusion of 10μmol/kg of Feridex. The effect of Feridex on signal intensity of the liver, CNR of lesion vs liver were assessed with quantitative analysis.Results Compared with plain scan, signal intensity of liver on Feridex enhanced T 2WI was significantly decreased and CNRs of lesion vs liver were significantly improved.Conclusion The defection of focal lesions in liver can be significantly with Feridex enhanced T 2WI and T 2 *WI. Feridex enhanced T 2WI is very useful for the diagnosis of focal hepatic lesions and Feridex enhanced T 1WI has potential for qualitative diagnosis of focal hepatic lesions.