摘要
用免疫组织化学染色方法检测了慢性乙肝患者肝组织内C erbB 2、FAS蛋白的表达 ,发现这两种蛋白有较高的阳性检出率。这些在肝细胞膜表达的蛋白质与肝细胞周围的淋巴细胞浸润有密切的关系 ,而且在碎屑样坏死灶周围有较强的表达。提示乙肝病毒可激发一些内源性基因的异常表达 ,诱导肝细胞的凋亡和坏死 ,参与对肝细胞的免疫损害。
C erbB 2 and FAS proteins were de te cted by immunohistochemical staining.The expression of C erbB 2 and FAS protei ns were much higher around the area of necrosis than other areas.Lymphocyte in filtration was found near the C erbB 2 p185 and FAS positive expression cells .P os itive rate of C erbB 2 protein corresponded with the increase of hepatic infla mmatory degree.Results showed that a series of genes were abnormally expressed i n hepatocytes after the infection of hepatitis B virus.These abnormal alteration s might lead to hepatocellular apoptosis,necrosis and hepatic immune lesion cons equently.
出处
《山西医科大学学报》
CAS
2001年第2期112-113,共2页
Journal of Shanxi Medical University