出生体重、孕周对学龄儿童肺功能的影响

The effects of low birth weight, gestational age on lung function in childhood

目的 研究出生体重、孕周与学龄儿童肺功能测定指标之间的关系。方法 测定 35名6～ 9岁低出生体重儿的身高、体重、肺功能 ,调查孕周以及被动吸烟情况 ,并与年龄、性别配对的正常出生体重儿童进行比较。结果 (1)低出生体重组儿童的用力肺活量 (FVC)、一秒钟用力呼气容积(FEV1)、FEV1占预计值 %、75 %肺活量最大呼气流量 ( V75)、5 0 %肺活量最大呼气流量 ( V50 )、 V50 占预计值 %、2 5 %肺活量最大呼气流量 ( V2 5)、 V2 5占预计值 %显著低于正常对照组 (P <0 0 5 ) ,与出生体重呈正相关 (r=0 2 11～ 0 2 87,P <0 0 5 )。 (2 )儿童各项肺功能测值与孕周无显著相关 (P >0 0 5 )。结论低出生体重学龄儿童大多数肺功能指标显著低于正常出生体重儿童。

Objective To evaluate the effects of low birth weight, gestational age on lung function in later childhood. Methods Height, body weight and lung function were measured in a cohort of 35 children with low birth weight (aged 6～9 y) and 35 healthy controls matched for sex and age with normal birth weight At the same time, we inquired their gestational age and passive smoking history The correlation analysis was used to analyze the relationship between lung function in these children and birth weight and gestational age. Results FVC,FEV 1,FEV 1% pred, 75 , 50 , 50% Pred,( 25 % Pred in children with low birth weight were significantly lower than those in children with normal birth weight( P <0 05) The lung function statistically positively correlated with birth weight( r =0 245～0 365, P <0 05), but not with gestational age ( P >0 05). Conclusion Low birth weight was positively correlated with most lung function parameters in childhood.