生、炙诃子对气管平滑肌收缩活动的影响

Effect of Unprepared and Prepared "He Zi" on Contraction of Isolated Trachea Smooth Muscle in Rabbits

本文采用乙酰胆碱、氯化钾诱发家免气管平滑肌收缩,观察生、炙诃子对气管平滑肌收缩活动的影响。结果表明:生诃子对乙酰胆碱和氯化钾诱发的气管平滑肌收缩无明显作用。而炙诃子对乙酰胆碱诱发的气管平滑肌收缩有明显的抑制作用,这种抑制作用可能与一氧化氮和前列腺素类物质的释放、cGMP及肾上腺素能受体无关,是非上皮依赖性的。炙诃子对氯化钾诱发的气管平滑肌收缩无明显作用。生、炙诃子作用的差别可能与鞣酸的含量不同有关。

Isolated trachea smooth muscle in rabbits induced by Ach or KCl was adopted to study the effect of unprepared and prepared 'He Zi'.The results showed that unprepared 'He Zi' couldn't affect the contraction of isolated trachea smooth muscle in rabbit induced by Ach or KCl, and that prepared He Zi couldn't affect the contraction of isolated trachea smooth muscle in rabbit induced by KCl. The results also showed that prepared 'He Zi'could significantly inhibit the contraction induced by Ach. The inhibition effect may not be associated with cGMP, adrenergic receptor, and release of NO and prostaglandin,and was epithelium independent. Maybe the different content of tannic acid contributed to the different effect between unprepared and prepared 'He Zi'.