甲磺酸多沙唑嗪治疗轻、中度高血压的临床疗效及安全性评价(英文)

Clinical Evalulation of Antihypertensive Efficacy and Safety of Administration of Doxazosin Mesylate in Mild to Moderate Essential Hypertension

目的 :评价多沙唑嗪治疗高血压的临床疗效和安全性。方法 :采用双盲双模拟随机对照的方法观察多沙唑嗪的疗效和安全性。经过 2周的清洗期 ,共有 43例病人入选 (试验组 2 2例 ,对照组 2 1例 ) ,按试验流程服药及监测血压、心率、肝肾功能及心电图等指标。结果 :经过临床 6周的药物治疗 ,临床有效率达 86 .4% ,其中显效率为 6 8.2 %。对肝肾功能无影响 ,无严重不良反应。结论 :多沙唑嗪是一种有效、安全的治疗轻。

OBJECTIVE:To evaluate the efficacy and safety of administration of doxazosin mesylate in mild to moderate essential hypertension.METHODS In the trial,43 patients meeting the creteria of enlistment after 2-week wash-out periods are randomized into two groups in term of double-blind manner,22 cases for doxazosin mesylate group,21 cases for Terazosin hydrochloride group.The patients will recept the scheduled medication intervention and blood pressure measure in order to assess the efficacy of antihypertension.Physical examnation, electrocardiogram,hematological and urinary test will be performed for monitoring the adverse events according to the trial protocol.RESULTS:The rate of effectiveness of doxazosin mesylate for hypertension controling is 86.4%.No severe adverse events such as the cardiovascular disorders appear in the 6-week trial except for the mild,toleratable headache in one patient.Doxazosin mesylate does not interfere with the hepatic and renal metabolism and impair their functions.CONCLUSIONS:Doxazosin mesylate adiministration is effective and safe in mild to moderate essential hypertension.