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注射用阿奇霉素治疗急性细菌性感染的临床研究

Clinical study on treating acute bacterial infections with Inj Azithromycin
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摘要 目的:评价国产注射用阿奇霉素治疗急性细菌性感染的疗效与安全性。方法:采用随机表法,将50例急性细菌性感染患者分成随机对照A组(20例)、随机对照B组(20例)和开放试验组(10例)。国产注射用阿奇霉素用于随机对照A组和开放试验组,每天0.5g,疗程5~7天;国产注射用乳糖酸红霉素用于随机对照B组,每天1.0g,疗程5~7天。结果:随机对照A组和随机对照B组治疗呼吸道感染的有效率分别为80%和90%,两组比较无显著性差异(P>0.05);随机对照A组和随机对照B组治疗泌尿道感染的有效率分别为90%和80%,两组比较无显著性差异(P>0.05);随机对照A组和随机对照B组的总有效率均为85%。开放试验组的总有效率为60%。随机对照A组、随机对照B组和开放试验组的细菌清除率分别为84%、92%和78%,组间比较无显著性差异(P>0.05)。结论:国产注射用阿奇霉素治疗急性细菌性感染安全可靠。 Objective:To evaluate efficacy and safety of domestic Inj. Azithromycin in the treatment of acute bacterial infections. Method: Fifty patients with various acute bacterial infections were randomly divided into 3 groups; 20 patients of Treatment Group A received domestic Azithromycin injection 0. 5 g each day; 20 patients of Control Group B received lactobionic acid erythromycin, injected 1 g each day,and 10 patients of Open Treatment Group received Azithromycin treatment with dose similar to Group A. Results; In Group A and Group B, the effective rates were 80% and 90% respectively (,P>0. 05) for patients with respiratory tract infections,and 90% and 80% (P>0. 05)respectively for urinary tract infections. In both of the 2 groups,the global effective rates for bacterial infections were 85%. In Open Treatment Group,the global effective rate was 60%. Conclusion:The domestic Inj. Azithromycin is effective and safe in treating acute bacterial infections.
出处 《上海医药》 CAS 2001年第3期117-120,共4页 Shanghai Medical & Pharmaceutical Journal
关键词 注射用阿奇霉素 急性细菌性感染 治疗 疗效 安全性 临床研究 azithromycin j lactobionic acid erythromycin bacterial infections
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