摘要
MUC1粘蛋白是一种大分子量的糖蛋白 ,主要存在于乳腺、胰腺、卵巢等上皮性组织和器官中。它在癌变上皮细胞表面高度异常表达 ,结构发生相应改变 ,从而成为免疫应答的靶点 ,并在乳腺癌的发展、转移、预后及免疫治疗中起到重要作用。
MUC1 is a large protein associated with glycosyl, which exist mainly in breast, pancreas, ovary and other epithelial tissues and apparatus. In adenocarcinomas, there is a highly and altered expression in MUC1. Due to such altered glycosylation, new epitopes appear on the cell surface that are absent in normal tissues .These epitopes will be new targets in immunotherapy, therefor, MUC1 can be used in the detection, prognosis and immunotherapy of breast cancer.
出处
《生物技术通讯》
CAS
2001年第2期130-131,139,共3页
Letters in Biotechnology
