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钾通道阻断剂TEA对大鼠全脑缺血后海马神经元损伤的保护作用 被引量：3

Neuroprotection by potassium channel blocker TEA on neuronal damage in rat hippocampus after global ischemia
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摘要 在大鼠四血管夹闭前脑缺血模型上 ,观察了侧脑室给予钾通道阻断剂四乙基铵 (TEA)和 4 氨基吡啶 (4 AP)对脑缺血后海马CA1区锥体神经元迟发性死亡的保护作用。结果发现 :再灌流 30min后给予TEA组CA1区存活的锥体细胞数明显高于生理盐水对照组 ,而再灌流 30min后给予 4 AP组和缺血前 30min给予TEA组的存活细胞数则与生理盐水对照组无明显差别。表明再灌流后给予TEA对脑缺血诱导的海马CA1区锥体神经元死亡具有明显的保护作用 ,提示钾通道可能在缺血后海马CA1区锥体细胞的迟发性死亡中发挥重要的作用。 The neuroprotective effects of tetraethylammonium (TEA) and 4-aminopyridine (4-AP), two potassium channel blockers, were examined on damaged hippocampal CA1 pyramidal neurons following 15 min of forebrain ischemia using the 4-vessel occlusion model in rats. The average neuronal density of the hippocampal CA1 subfield was significantly higher in rats administered intracerebroventricularly 30 min postischemia with TEA when compared with that of the saline control group. However, administrations of 4-AP 30 min posterior to, or TEA 30 min prior to ischemia showed no apparent effect. The present study indicates that postischemic application of TEA can protect hippocampal CA1 pyramidal neurons from ischemic insult, suggesting that potassium channel may play important roles in neuronal death of hippocampal CA1 region after transient forebrain ischemia.
作者 黄浩 李晓明 高天明
机构地区 第一军医大学生理学教研室
出处 《中国神经科学杂志》 CSCD 2001年第2期173-176,共4页
基金 国家自然科学基金! (NNSF 3 9970 2 65 ) 广东省自然科学基金! (NSFGP 990 3 95 ) 军队杰出青年基金项目资助
关键词 四乙基铵 钾通道 脑缺血 海马 大鼠 TEA 4-AP 4-氨基吡啶 tetraethylammonium potassium channel ischemia hippocampus rat
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献15

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同被引文献67

  • 1黄广,林霓阳,肖育.K_(ATP)开放剂克罗卡林对新生鼠缺氧缺血性脑损伤细胞凋亡的影响[J].中国妇幼保健,2006,21(7):946-948. 被引量：2
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中国神经科学杂志
2001年 第2期

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