米索前列醇口服及阴道给药用于足月妊娠促宫颈成熟及引产效果

Cervical Ripening and Labor Induction Efficacy in Women at Term with Misoprostal by Two Methods

研究米索前列醇口服及阴道给药对于足月妊娠促宫颈成熟效果与宫颈成熟度的关系及其引产效果 .选择有引产指征的足月妊娠妇女 12 0例 ,根据宫颈Bishop评分随机分为Bishop评分≤ 6分组 (A)及Bishop评分≥ 7分组 (B) .各组根据用药途径分为阴道给药组 (A1,B1组 )及口服给药组 (A2 ,B2 组 ) .米索前列醇片 ,5 0 μg ,Q4h ,总量≤ 40 0 μg ,根据各组的用药途径分别口服或阴道给药 .结果 :宫颈Bishop评分≤ 6分者 ,米索前列醇阴道给药宫颈评分增加显著高于口服给药组 ,引产时间、米索前列醇用量显著低于口服给药组 (P <0 0 5 ) ;Bishop评分≥ 7分者 ,米索前列醇阴道给药宫颈评分增加 ,引产时间、米索前列醇用量与口服给药组未见显著性差异 (P >0 0 5 ) .宫颈Bishop评分≤ 6分者 ,米索前列醇阴道给药有显著促宫颈成熟及诱发宫缩的作用 ,口服给药仅有诱发宫缩的作用 ;Bishop评分≥ 7分者 ,阴道给药及口服给药均有相似的促宫颈成熟及诱发宫缩的作用 .

To determine the cervical Bishop score with the efficacy of misoprostal as a cervical ripening and inductionof labor agent in women at term per vagina or peroral (po). Methods:The sample consists of 120 women at term who had clinical induction for labor induction. They were randomly allocated into 2 groups by cervical Bishop score. Group A were Bishop score≤6, Group B Bishop score 37. Each group was-divided into two subgroup by route of using misoprostal, peroral (A 1,B 1); per vagina(B 1, B 2). The women whose cervical Bishop score≤6 Bishop score increase per vagina was significantly higher than per oral, but the labor induction time and misoprostalas dose was significant lower than per oral.The women whose cervical Bishop score≥7, labor induction time and misoprostalas dose per vagina were not significantly different from the women per oral. When cervical Bishop score ≤6, misoprostalas per vagina can significantly increase Bishop score and contract uterine revulsant, but mi soprostalas po only contract uterine revulsant. When cervical Bishop score≥7, misoprostalas per vagina or po had similar cervical ripening and labor induction efficacy.