HP-CagA基因型与胃十二指肠溃疡相关性的病例对照研究

Contrast Study of Reaction with HP-CagA Type and Peptic Ulcer

探讨昆明地区胃十二指肠溃疡与HP -CagA感染的相互关系 .方法 :采用病例对照研究 ,病例组活动性十二指肠溃疡 (DU) 4 8例 ,胃溃疡 (GU) 4 8例 .对照 1组为同期住院的本科及其它科住院的非胃十二指肠疾病患者 48例 .对照 2组为同期普查的健康人群 48例 .血清HP -CagA -IgG抗体的检测采用斑点金免疫渗泸法 (DIGFA) .结果 :192例中 ,HP -CagA -IgG总的检测率为 5 0 5 2 % (97/ 192 ) ,其中DU组85 42 % (4 1/ 48) ,GU组 70 83 % (34/ 48) ,非消化系统疾病组 2 5 0 % (12 / 48) ,健康人组 2 0 83 % (10 /48) .Du组的HP -CagA -IgG阳性率显著高于两个对照组 (χ2 =2 0 10 3 ,P <0 0 0 0 1) ;GU组CagA -IgG阳性HP感染率显著高于两个对照组 (χ2 =13 92 1,P <0 0 0 1) .结论 :提示昆明地区CagA阳性的HP感染与DU和GU的发病密切相关 ;高毒株HP感染是溃疡形成的重要因素 .

Studying the relation of HP-CagA type and peptic ulcer in Kunming area.We use contrast research of cases. Patient group have 48 duodenal ulcers (DU) and 48 gastric ulcers (GU). Control group l has 48 patient of no peptic ulcer (DU and GU). Control group 2 has 48 healthy people. We check up serum HP-CagA-lgG to use DIGFA. HP-CagA-lgG positive rate is 50 52%(97/l92), in which DU group is 85 42%(4l/48), GU group is 73 83%(34/48), control group l is 25 0%(l2/48), and control group 2 is 20 83% (l0/48). HP-CagA-lgG positivera te of DU group is significantly higher than two control groups (χ 2=20 103,P<0 000?1). HP-CagA-lgG positive rate of GU group is significantly higher than two control groups ( χ 2=l3 92l,P<0 001). Conclusion: CagA+HP infection is closely related to PU. High toxicity HP isimportant factor leading to ulcer