狼疮肾炎伴狼疮危象37例临床分析

Clinic Analysis of 37 LN Cases with Crisis

为了探讨狼疮性肾炎伴狼疮危象的危险因素及其预后 ,收集了符合狼疮性肾炎伴狼疮危象的患者37例进行临床分析 .结果 :狼疮性肾炎并发狼疮危象其病理类型以WHOⅣ型或WHOⅤ型为主 .其诱因有感染、不规则的激素治疗、劳累及过度日晒 .在甲基强的松龙和环磷酰胺联合冲击治疗的同时 ,配合必要的血透或腹透 ,总有效率为 5 9 46 % ,死亡率为 2 9 73 % .结果表明其预后与病理类型、大量蛋白尿 ,C3 以及病变累及脏器的数目密切相关 .

In order to investigate the risky factor and the pr ognosis of lupus nephritis (LN) with crisis. The data of 37 cases of LN with crisis was analyzed. The results showed that LN with crisis often occurs with the patients whose pathologic type is WHO Ⅳ of WHOⅤ, the inducement are infection and irregular therapy. A necessary hemodialysis and peritoneal dialysis were realized at the same time while the pulse therapy of large dosage methypredrisolone (MP)combined with CTX was administrated. The total effective rate was 59 46% and mortality was 29 73% It shows that the prognosis is related to the pathologic type, massive proteinuria, C 3 and the number of involving organs.