脑囊虫病、结核性脑膜炎及特发性癫痫患者脑脊液前白蛋白和NAG等酶分析

Determination of CSF prealbumin and four kinds of enzymes in cerebral cysticercosis,tuberculous meningitis and epilepsy

目的 :了解脑囊虫病 (CC)、结核性脑膜炎 (CT)及特发性癫痫 (Ep)患者脑脊液 (CSF)中前白蛋白 (PA)、肌酸激酶B亚基 (CK B亚基 )、N 乙酰 β D 氨基葡萄糖苷酶 (NAG)、天门冬酸氨基转移酶 (AST)、乳酸脱氢酶 (LD)的变化与临床意义。方法 :对CC患者 18例 ,CT患者 10例 ,Ep患者 15例 ,正常对照组 2 0例CSF中PA和 4种酶活性进行了测定。结果 :5种物质的水平在CC组和CT组患者CSF中均有异常改变 ,CC组CSFPA与总蛋白水平显著低于CT组 ,CK B亚基高于CT组 ,而NAG、LD与AST活性在 2组间差异无显著性。Ep组仅CSFPA水平降低 ,其降低程度介于CC组与CT组之间 ,CK B亚基高于CT组 ,与CC组无明显差别。 3种疾病中每种疾病CSF中 5种物质浓度的变化均无相关性。结论 :检测CSFPA与 4种酶活性在鉴别诊断CC、CT、Ep时具有一定临床意义。

Aim: To investigate the changes of cerebrospinal fluid (CSF) prealbumin (PA),creatinekinase B subunit(CK B subunit), N acetyl β D glucosamindase(NAG), aspartateamino trasferase (AST) and lactate dehydrogenase(LD) in patients with cerebral cysticercosis(CC), cerebral tuberculosis(CT) and epilepsy(Ep)and their clinical significance . Method: The levels of PA,CK B subunit, AST and LD were determined in CSF of the patients in three groups Results: Levels of CSF PA and four enzymes were all abnormal in the CC and CT groups. The level of CSF PA of the CC group was the lowest among the three groups. The activity of CK B subunit in the CC group was higher than that in the CT , but it was lower than that in the Ep group. There were no significant differences between activity of three enzymes, NAG,LD and AST, in CC and CT groups. The level of CSF total protein (T P) of the CT group was higher than that of the CC group. CSF PA in the Ep group decreased between the CC and CT groups.CK B subunit in the Ep group was higher than that in the CT.There was no correlation among the change of 5 components among patients with CC,CT or Ep. Conclusion: The results suggest that the measurement of 5 components in CSF is useful for diagnosis of CC,CT and Ep