2维和3维采集对脑葡萄糖代谢半定量指标的影响

Effect on Semiquantitive Analysis for Brain Glucose Metabolism with 2 or 3 Dimensional PET Scan Respectively

目的 研究 2维 (2D)和 3维 (3D)采集对脑葡萄糖代谢半定量指标有无明显影响 ,在实际工作中可否灵活采用 .方法 36例无神经疾病病史、症状和体征 ;脑磁共振成像无异常的受检者分为 2组 ,其中 2D组 15例 ,3D组 2 1例 .静脉注射18F -FDG后行PET脑断层显像 ,经计算机滤波反投影重建获得横断面、冠状面、矢状面断层影像 .横断面影像经处理层厚为 0 .5cm ,按常规分别选取代表双侧额叶、顶叶、颞叶、枕叶、小脑皮质的三层影像 ,勾画出各结构的边界 ,依据体重和注射剂量等参数求出平均SUV值 .将上述各部位的平均SUV值进行左右比较 ,计算出比值 ,称R(L/R) .将各脑叶的平均SUV值与小脑平均SUV值进行比较 ,计算出比值 ,称R(C/Cb) .上述数据进行统计学处理 .结果 2D和3D两组双侧额叶、顶叶、颞叶、枕叶、小脑皮质的平均SUV值 ,R(L/R) 和R(C/Cb) 皆差异无显著性 .结论 2D和 3D采集各有优缺点 ,当采用SUV作为半定量指标对脑葡萄糖代谢状况进行评价时 ,两种采集方式对结果无明显影响 ,故可根据实际情况 。

objective To explore the effect on semiquantitive analysis for brain glucose metabolism with 2 or 3 dimensional PET scan respectively.Methods 36 normal persons were divided into two group,15 for 2D,21 for 3D.PET scans were done after 40 minutes of injection of FDG .The transaxial,the coronal,the saggital were gotten through computer reconstruction. The transaxial slice density was 0.5cm. The borders ofbilateral frontal lobes , bilateral parietal lobes , bilateral tempt lobes ,bilateral occipital lobes and bilateral cerebellum were drawn. According to ROI, weight and injection dose of FDG,mean SUVs in all above lobes were gotten. R(L/R)s from Mean SUVs in the left lobes via those in the right were caculated. R(C/CB)s from mean SUVs in different brain lobes via those different cerebellum lobes were also caculated. Results There was no significance between 2D and 3D about SUV ratios of R(L/R)s and R(C/CB)s . Conculsions The semiquantitive analysis for brain glucose metabolism could not be affected by PET scan methods. According to patients condition , 2D or 3D could be chosen to be used without affecting semiquantitive analysis.