P21和P185在颊粘膜上皮良性和恶性病变中的表达及意义

Expression of P21 and P185 in Benign and Malignant Epithelia of Cheek Mucosa

采用免疫组化ＡＢＣ法检测Ｐ２１和Ｐ１８５在正常颊粘膜上皮、慢性非特异性炎症病变、鳞状细胞癌及其癌旁组织中的表达，并进行图像分析。结果显示，Ｐ２１和Ｐ１８５在鳞癌和部分癌旁组织中的表达明显高于正常颊粘膜上皮和炎症病变，二者具有明显的相关性。

To analyze the expression of P21 and P185 in normal epithelia, chronic nonspecific inflammatory epithelia, squamous cell carcinoma and epithelia immediately adjacent to carcinoma of cheek mucosa, immunohistochemistry technique and image analysis technique were used. The results showed: there was excellently higher expression of P21 and P185 in squamous cell carcinoma and epithelia immediately adjacent to carcinoma than in normal and inflammatory epithelia of cheek mucosa, which were compactly correlative.