小牛皮胶原对新骨形成影响的定量组织学研究

Histologic Study for Effects of Ox Collogen in Forming of New Bone with Quantitative Method in Animal Models

将小牛皮胶原植入１０只成年狗颌骨内，在不同时段取标本进行组织学光镜检测和定量分析。结果显示，此材料组织相容性良好，不影响新骨形成，材料与骨组织间无纤维被囊形成，与新骨直接结合，材料最后在机体内大部分降解，为宿主新生骨组织替代。

In this study, collagen was implanted into mandibular defects of 10 dogs. After operations, the samples were examined with microscope and quantitative method at 10 periods. Results showed that collagen did not affect bone growth and new bone grew into collagen directly. There was no fibrous capsule between collagen and new bone. Eventually, majority of collagen was resorbed and replaced by bone tissue. It was concluded that collagen has a good histocompatibility.