实验性口腔粘膜炎性损害的抗氧化防治机理研究Ⅱ.口腔粘膜谷胱甘肽过氧化物酶的变化规律

The Mechanisms of Antioxidant Against Inflammatory Lesion in Animal Oral Mucosa Ⅱ. A Study of Glutathione Peroxidase

研究不同时段鼠颊囊组织中谷胱甘肽过氧化物酶（ＧＰｘ）的活性变化规律，并分析了ＧＰｘ清除脂质过氧化产物丙二醛（ＭＤＡ）的作用效能。结果显示：ＳＯＤ组早期（８ｈ）ＧＰｘ活性明显下降，但ＭＤＡ含量却未增高；模型组８ｈ～３ｄ时ＧＰｘ活性正常，但８ｈ时ＧＰｘ清除ＭＤＡ的效能却明显降低。上述结果提示：外源性ＳＯＤ可能具有代替ＧＰｘ清除过量ＭＤＡ。

In order to understand the mechanisms of superoxide dismutase (SOD) against inflammatory lesion in hamster cheek pouch, glutathione peroxidase (GP x) activity in the cheek pouch mucosa was assayed in different time. The efficacy of GP x scavenging lipid peroxide was also measured. In the SOD group GP x activity decreased significantly in the early stage (8 h). But the level of lipid peroxide in the SOD group not increase at the same time. The results of the model group were contrary. It was implied that exigenous SOD scavenged lipid peroxide in the oral mucosa sufficiently in stead of GP x.