埋入5-氟尿嘧啶植入剂后家兔血清及肌肉组织中药物浓度的测定

DETERMINATION OF DRUG CONCENTRATION IN SERUM AND MYOIDEUM AFTER 5-FLUOROURACIL IMPLANTS WERE IMPLANTED IN RABBIT

埋入5-氟尿嘧啶(5-Fu)植入剂后.用高效液相色谱法测定家兔血清中及埋植处肌肉组织的药物浓度.结果表明:埋入植入剂后,5-Fu在体内能缓慢、恒定、长时间地释放,使埋植处局部维持较高浓度.而血药浓度长期稳定在较低范围.因此,该剂型的研制对于提高5-Fu的抗肿瘤疗效,降低其毒性具有积极的意义.

Drug concentration in serum and myoideum around the implanting sites were measured by HPLC after 5-fluorouracil implants were implanted in the paravertebral muscles of rabbits. It was concluded that 5-Fu implants can release slowly,stably and persistently. Drug concentration in myoideum around the implanting sites can maintain at a higher level, however that in serum at consistently lower range. So the preparation of dosage form will be expected to improve the antineoplastic therapeutic effects and decrease the toxicity of 5-Fu.