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磷脂过氧化氢物谷胱甘肽过氧化物酶与精子成熟 被引量：7

Advances in Phospholipid Hydroperoxide Glutathione Peroxidase and Sperm Maturation
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摘要 磷脂过氧化氢物谷胱甘肽过氧化物酶 (PHGPx)基因位于人类 19号染色体上 ,是第二个被鉴定的细胞内硒依赖的谷胱甘肽过氧化物酶 ,是一种相对分子质量 (Mr)为 190 0 0的单体酶 ,它通过催化脂质过氧化物的减少来保护细胞不受脂质过氧化物介导的损害。PHGPx曾被认为是一种保护质膜的普通的抗氧化酶 ,现在认为其具有多种功能 ,如抑制脂肪氧化酶和在人类精子成熟过程中变成一种线粒体内囊的无酶活性的结构蛋白成分 ,即PHGPx在精子细胞内以可溶性过氧化物酶的形式存在 ,而在成熟精子以无活性、被氧化交叉结合。 The gene encoding selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) is located in chromosome 19 in human. PHGPx is the second identified as Se dependent intracellular glutathione peroxidase (PHGPx) which is a 19 000(Mr), monomeric enzyme. PHGPx originally presumed to be a universal antioxidant enzyme protecting membrane lipids, appears to have adopted a variety of specific roles like silencing lipoxygenases and becoming an enzymatically inactive structural component of the mitochondrial capsule during sperm maturation. In other words, PHGPx exists as a soluble peroxidase in spermatids but persists in mature spermatozoa as an enzymatically inactive, oxidatively cross linked, insoluble protein.
作者 李伟涛 朱伟杰 潘善培
机构地区 暨南大学生殖免疫中心
出处 《中华男科学杂志》 CAS CSCD 2001年第2期109-112,共4页 National Journal of Andrology
关键词 硒 磷脂过氧化氢物谷胱甘肽过氧化物酶 精子 精子成熟 Se PHGPx Sperm Sperm maturation
分类号 R321.1 [医药卫生—人体解剖和组织胚胎学]
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参考文献24

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同被引文献107

引证文献7

二级引证文献54

中华男科学杂志
2001年 第2期

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