慢性肾功能不全患者血层粘连蛋白和α_1-微球蛋白测定意义及评价

EVALUATION AND SIGNIFICANCE OF THE DETECTION OF SERUM LAMININ AND α_1 -MICROGLOBULIN OF THE PATIENS WITH CHRONIC RENAL FAILURE

目的 :为了探讨慢性肾功能不全患者血层粘连蛋白 (LN)和α1-微球蛋白 (α1-MG)含量的变化及临床意义。方法 :79例慢性肾功能不全患者以血肌酐 (Cr)水平分为氮质血症组和尿毒症组 ,用放免分析法对全部患者血清LN和α1-MG进行检测。结果 :氮质血症组与尿毒症组LN和α1-MG分别与对照组相比均有显著性差异 (P <0 .0 2 ) ,尿毒症组血清α1-MG水平明显高于氮质血症组 (P <0 .0 1) ,尿毒症组与氮质血症组血清LN水平无差异 (P >0 .0 5 )。结论

Objective:To investigate the clinical significance and alternation of Serum Laminin (LN) and α 1-microglobulin(α 1-MG) concentrations of the patients with chronic renal failure.Methods:30 control subjects and 79 patients were involved in this study,79 patients were divided into azotemia group and uremia group by serum creatitine,serum LN and α 1-MG concentrations were detected by radioimmunoassay.Results:Serum LN and α 1-MG in azotemia group and uremia group were remarkably higher than those in normals respectively (P<0.02),serum α 1-MG in uremia group was significantly higher than that in azotemia group (P<0.01),While serum LN in uremia group was no different from that in azotemia group (P>0.05).Conclusions:Serum LN and α 1-MG may be one of the laboratory parameters of chronic renal failure.