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IL-18的抗肿瘤作用 被引量：3

Antitumor Effects of IL-18
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摘要 白细胞介素 18(IL 18)是近年发现的新型细胞因子 ,具有诱生IFN γ、增强NK细胞活性、增强Th1型免疫反应、抗肿瘤作用等多种生物学功能 ,是一种应用前景较好的抗肿瘤细胞因子。综述IL 18的发现与来源、理化特性、生物学活性及抗肿瘤机理。 Interleukin 18 is a new type of cytokine which is focused on in recent years.It can induce the produce of interferon gamma,improve the activity of natural killer cells and Th1 type immunoreaction and has antitumor effects.The cytokine of Interleukin 18 has widely utilized foreground.The article describes the finding,physi chemical property,biological activity and the antitumor machinism of Interleukin 18.
作者 宋希林 徐忠法 陈玖玲
机构地区 山东省肿瘤防治研究院普外科 潍坊市拖拉机厂职工医院
出处 《肿瘤防治杂志》 2001年第2期187-190,共4页 China Journal of Cancer Prevention and Treatment
关键词 白细胞介素18 肿瘤 预防 治疗 interlukin 18 neoplasm prevention treatment review
分类号 R730.2 [医药卫生—肿瘤]
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参考文献16

  • 1Okamura H,Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells [J]. Nature, 1995, 378(6552): 88 - 91.
  • 2Kohno K, Kurimoto M.Interleukin 18, a cytokine which resembles IL1 structurally and IL-12 functionally but exerts its effect independently of both[J]. Clin Immunol. Immunopathol, 1998,86( 1 ): 11 - 15.
  • 3De Saint Vis B, Fugier-Vivier l, Massacricr C, et al. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activiation[J] .J Immunol, 1998,160(4): 1666 - 1676.
  • 4Ushio S, Namba M, Okura T, et al. The molecular characters of Interleukin 18 [ J ]. J Immunol, 1996,156( 11 ) :4274 - 4279.
  • 5Matsumoto S,Tsuji-Takayama K,Aizawa Y, et al. Interleukin-18 activates NF-kappa B in murine T helper type 1 cells[J] .Biochem Biophys Res Commun, 1997,234(2):454 - 457.
  • 6Tsuji Takayama K,Matsumoto S, Koide K,et al. Interleukin-18 induces activation and association of p56(lck) and MAPK in a murine Th1 clone [J]. Biochem Biophys Res Commun, 1997,237( 1 ): 126 ～ 130.
  • 7Hashimoto W,Osaki T,Okamura H,et al. Differential antitumor effects of administration of recombinant IL-12 are mediated primarily by FasFas ligand and pefforin-inducecl tumor apoptosis , respectively [J ]. J Immunol, 1999,163(2) :583 - 589.
  • 8Osaki T, Peron JM,Cai-Q,et al. INF-gamma-inducing factor/IL-18 administration mediates INF-gamma and IL-12-independent antitumor effects[J] .J Immunol, 1998,160(4): 1742 - 1749.
  • 9Hara I, Nagai H,Miyake H,et al. Effectiveness of cancer vaccine therapy using cells transduced with the imterleukin-12 gene combined with systemic interleukin-18 administration [J ]. Cancer Gene Ther, 2000,7(1):83-90.
  • 10Hyodo Y,Matsui K,Hayashi N,et al. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor [J ]. J Immunol, 1999,162(3): 1662 - 1668.

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二级引证文献19

肿瘤防治杂志
2001年 第2期

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