性病患者金黄色葡萄球菌感染耐药性研究

Drug Resistance of Staphylococcus aureus in Patients with Sexually Transmitted Diseases

目的 研究男性性病后泌尿生殖系金黄色葡萄球菌感染及其对各类抗生素的耐药性 ,旨在协助指导临床合理用药。方法 采用美国 NCCL S药敏试验纸片扩散法 ,检测从男性尿道及前列腺液标本中分离的金黄色葡萄球菌的耐药性。结果 金黄色葡萄球菌对常用 33种抗生素的耐药率以头孢哌酮、阿米卡星 (丁胺卡那 )、头孢呋辛、头孢唑林、新霉素、头孢曲松 (头孢三嗪 )、头孢噻肟、头孢他啶耐药率较低 ,分别为 2 5 .8%、2 6 .5 %、2 7.6 %、2 9.9%、30 .8%、36 .1%、41%、43.9% ;青霉素类、氟喹诺酮类、其他氨基糖苷类、红霉素、氯林可霉素、多西环素(强力霉素 )、壮观霉素等耐药率很高均在 70 %～ 10 0 % ;有 2 0株对 2 0余种抗生素耐药 ;仅对 2株做万古霉素敏感试验 ,2株均耐药。结论 金黄色葡萄球菌在男性性病泌尿生殖系感染占首位 ;这些菌株对各类抗生素有较高的耐药性 ,而且呈多重耐药 ;

OBJECTIVE To study the infection of Staphylococcus aureus in urinary and reproductive system after the male sexually transmitted diseases and the drug resistance to different antibiotics.It′s aim is to help doctors to use antibiotics rationally.METHODS Using the U.S.NCCLS antibacterial disk susceptibility test,we measured drug resistance of S.aureus from the male sexual urinary tract and prostate gland.RESULTS In commonly used 33 antibiotics,the drug resistance rates of S.aureus to cefoperazone,amikacin,cefuroxime,cefazolin,neomycin,ceftriaxone,cefotaxime,ceftazidime are low,they are25.8%,26.5%,27.6%,29.9%,30.8%,36.1%,41%,43.9%, respectively.The drug resistance rates to penicillin,quinolone antibacterials,the other aminoglycosides, erythromycin, clindamycin,doxycycline,spectinomycin are high,they are between 70% to 100%.There are 20 strains of S.aureus resistant to more than 20 sorts of antibiotics.Only making vancomycin susceptible test of 2 strains of S.aureus,they are both drug resistant. CONCLUSIONS S.aureus are in the first place in urinary and reproductive system inflammation after the male sexually transmitted diseases.These bacteria have higher drug resistance to different antibiotics and they are multiple resistant,we should pay attention to prevalance and spread of vancomycin resistant S.aureus.