摘要
探讨葛根汤的抗炎作用机制。结果表明 ,葛根汤 8 2g kg、16 4g kg致炎前三天开始以灌胃方式连续给药 2 1d ,可明显抑制致炎 19d的佐剂性关节炎大鼠关节液中IL 1β、TNF α的活性及PGE2 的含量。提示葛根汤抑制炎症区域细胞因子的活性和炎症介质的含量 ,是葛根汤抗炎作用的机理之一。
The aim of this study was to discuss the anti-inflammation mechanism of GeGen Decoction (GGD).The results showed GGD could significantly inhibit the activity of IL-1 β/TNF-α and decrease the level of PGE\-2 in the joint of Adjuvant Arthritis rats by giving GGD (8.2g/kg,16.4g/kg,ig) for three days before modeling till 21 days.It indicates GGD can inhibit the activity of cytokines in the inflammatory area and decrease the level of inflammatory media,which may be one of its anti-inflammation mechanisms of GGD.
出处
《中国实验方剂学杂志》
CAS
2001年第3期29-31,共3页
Chinese Journal of Experimental Traditional Medical Formulae
