次声作用后大鼠血浆中血管紧张素Ⅱ含量的改变(1)

Change of angiotensinⅡcontent in the plasm after infrasound effect on rats (1)

目的 观察次声作用大鼠后 ,血浆内血管紧张素Ⅱ (AⅡ )含量的变化。方法 用 16Hz ,13 0dB次声 ,作用 1、7、14、2 1d ,2h/次·d-1。分别于作用后 0 .5、6、12、18、2 4h观察大鼠血浆内AⅡ含量的变化。结果 大鼠血浆内AⅡ含量在次声作用 1d后 ,在 2 4h内与对照组相比持续性增高 (P <0 .0 1)。次声作用 7d ,与对照组相比 0 .5h已开始增高 (P <0 .0 1) ,12h达高峰 ,而后下降 ,至 2 4h低于对照组 (P <0 .0 5 )。次声作用 14d ,与对照组相比 0 .5h已显著增高 ( P <0 .0 1) ,6h、12h与对照组差异无显著性意义(P >0 .0 5 ) ,18、2 4h复呈显著增高 (P <0 .0 1)。次声作用 2 1d ,与对照组相比 0 .5h已开始增高 (P <0 .0 5 ) ,12h达高峰 ,而后下降 ,至 2 4h与对照组差异无显著性意义 (P >0 .0 5 )。结论 次声作用后 ,大鼠血浆内AⅡ含量随次声作用时间的不同而呈不同的规律性改变。

Objective To observe rat plasma angiotensin Ⅱ (AⅡ) content change after exposed to infrasound. Methods Infrasound was exposed to rats for 1,7,14,21 d and two hours every time in a day. After half, six, twelve, eighteen and twenty four hours, AⅡcontent change was observed. Results After exposed to infrasound for 1 d,AⅡcontent continued to increase in the next twenty four hours compared to control group (P< 0.01 ) .After infrasound exposure for 7 d,AⅡ began to increase after half hour compared to control group (P< 0.01 ) , reached maximum at twelve hours, then began to decrease and turned less than that in the control group at twenty four hours(P< 0.05 ).After infrasound exposure for 14 d, AⅡ increased significantly compared to the control group(P< 0.01 ).At six hours and twelve hours,there was no significant difference (P> 0.05 ) ,it increased notably at eighteen hours and twenty four hours(P< 0.01 ).After infrasound exposure for 21 d, AⅡ began to increase at half hour compared to the contol group(P< 0.05 ),reache maximum at twelve hours,then began to decrease and showed no significant difference at twenty four hours(P> 0.05 ).Conclusion After infrasound exposure, there was irregular change of rat plasma AⅡ content at different times.