肺纤维化患者血清Ⅲ型前胶原、Ⅳ型胶原及脯氨酸肽酶含量的改变

Changes of the blood levels of type Ⅲ procollagen,type Ⅳ collagen and prolidase in patients with pulmonary fibrosis.

目的 探讨肺纤维化患者血清Ⅲ型前胶原 (PCⅢ )、Ⅳ型胶原 (CⅣ )及脯氨酸肽酶 (PLD)的含量变化及临床意义。方法 对 2 5例肺纤维化患者和 2 0例健康人采用放射免疫分析法检测血清中PCⅢ及CⅣ的含量 ;用比色法检测血清中PLD含量。结果 肺纤维化患者血清中PCⅢ及CⅣ含量明显增高 ,同时PLD含量亦增加 ,与健康对照组比较 ,差异有显著性 (P <0 .0 1) ,且三者之间呈明显正相关 (P <0 .0 5或 <0 .0 1)。结论 肺纤维化患者血清PCⅢ、CⅣ及PLD的水平可作为反映肺纤维化改变的参考指标。

Objective To explore the changes of PCⅢ(type Ⅲ procollagen),CⅣ(type Ⅳ collagen)and PLD(prolidase)in the serum of patients with pulmonary fibrosis and to shed light on the relevant clinical significance.Methods The blood levels of PCⅢ,CⅣ and PLD in 25 patients with pulmonary fibrosis and 20 normal subjects were measured by radioimmunoassay and colorimetry.Results The blood levels of PCⅢ,CⅣ and PLD in the patients were significantly higher than those in normal subjects.There were positive correlations between PCⅢ,CⅣ and PLD.Conclusion The above results suggest that the levels of PCⅢ,CⅣ and PLD in the serum may be used as an effective reference index in diagnosing the pulmonary fibrosis.