硬膜外腔注射脉络宁治疗腰椎间盘突出症及对脑脊液中强啡肽A的影响

Treatment of Lumbar Intervertebral Disk Prolapse by Estradural Injection of Mailuoning and Its Influence on Dynorphin A in Cerebrospinal Fluid

目的 :探讨硬膜外注射中药对机体疼痛调节功能的调理作用。方法 :用硬膜外注射中药脉络宁的方法治疗腰椎间盘突出症患者 (实验组 ) 2 0例 ,设对照组 2 0例 ,并观察两组患者治疗前后脑脊液中强啡肽A(Dyn A)的自发释放趋势 ,以判定其疗效。结果 :治疗后实验组Dyn A含量明显升高 ,和健康组比较差异无显著性 ,对照组Dyn A含量与健康组比较差异有显著性 (P <0 0 5)。结论 :硬膜外腔注射脉络宁对机体的疼痛调节功能有调理作用 ,通过提高Dyn

Objective: To explore the modulating effects of extradural injection of Mailuoning on analgesic function. Methods: Twenty patients of lumbar intervertebral disk prolapse were treated by extradural injection of Mailuoning, the spontaneous release of dynorphin A (Dyn A) in cerebrospinal fluid (CSF) before and after treatment were measured and compared with that of the 20 cases in the control group to determine the therapeutic effect of Mailuoning. Results: After treatment, the concentration of Dyn A in CSF in the treated group increased remarkably, but displayed no significant difference to normal healthy group (P>0 05), while that in the control group there was significant difference between them (P<0 01). Conclusion: Mailuoning has the modulatory effect on analgesia function and lumbar intervertebral disk prolapse was treated by means of its Dyn A elevating action.