丹参、黄芪对肝硬化门静脉高压患者血流动力学及肝纤维化指标的影响

Influence of Salvia Miltiorrhizae and Astragalus membranaceus on Hemodynamics and Liver Fibrosis Indexes in Liver Cirrhotic Patients with Portal Hypertension

目的 :观察丹参、黄芪对肝硬化门静脉高压血流动力学及肝纤维化指标的影响。方法 :选择84例肝硬化门静脉高压患者 ,随机分为A(常规治疗 )组 4 2例和B(常规加丹参、黄芪治疗 )组 4 2例 ,分别于治疗前、治疗 1、2、3个月后监测门静脉内径 (Dpv) ,脾静脉内径 (Dsv) ,门静脉血流速度 (Spv)、脾静脉血流速度 (Ssv) ,门静脉血流量 (Qpv) ,脾静脉血流量 (Qsv) ,及肝纤维化指标血清透明质酸 (HA)、Ⅲ型前胶原肽(PCⅢ )、层粘蛋白 (LN)各 1次 ,并作对比分析。结果 :B组Dpv、Dsv缩小 ,Spv、Ssv加速 ,Qpv、Qsv减少 ,与A组比较差异均有显著性 (P <0 0 5,P <0 0 1)。且HA、PCⅢ、LN有明显改善 ,与A组比较差异也有显著性 (P <0 0 1)。结论 :丹参、黄芪能较好地改善肝硬化门静脉高压 。

Objective: To observe the influence of Salvia miltiorrhiza (SM) and Astragalus membranaceus (AM) on hemodynamics and liver fibrosis indexes in patients of liver cirrhosis with portal hypertension. Methods: Eighty four cases of liver cirrhosis were enrolled and divided randomly into two groups, 42 in each. The control group was treated with conventional therapy and the tested group treated with SM and AM. The parameters, including diameter of portal vein and splenic vein (Dpv and Dsv), speed of blood flow in portal vein and splenic vein (Spv and Ssv), quantity of blood flow in portal vein and splenic vein (Qpv and Qsv) as well as liver fibrosis indexes, such as HA, PCⅢ and LN, were determined before, 1, 2 and 3 months after treatment. Results: After treatment, in the tested group, Dpv and Dsv decreased, Spv and Ssv increased, and Qpv and Qsv reduced, showing a significant difference in comparison with those in the control group (P<0 05 or P<0 01). The liver fibrosis indexes were improved significantly in the tested group, also showed significant difference from those in the control group (P<0 01). Conclusion: SM and AM could improve portal hypertension effectively in liver cirrhosis patients, one of the mechanism may be related with the improvement of liver fibrosis.