摘要
通过累积计分法、家蝇寿命实验、正交试验等方法筛选出杜仲、覆盆子等七味中药组成抗衰延寿方。实验证明该方能延长家蝇寿命,提高大鼠SOD、SeGSH-R、CAT活性,抑制过氧化脂质和脂褐素的形成及MAO—B活性,提高HDLc,降低Tc、LDLc,还能降低肺、脑游离核糖核酸酶活性,提高肺、脑核糖核酸酶抑制因子(RI)活性。急慢性毒性实验证明该方无毒性。
Prescription for anti-aging and prolonging lifespan consisted of 7 Chinese herbs including eucommia bark and raspberry which were elected from 100 classic prescriptions for antiaging through cumulative method,essay on lifespan of common house-fly and orthogonal test. Expe rimental results showed that this prescription could prolong the lifespan of common house-fly, enhance the activity of SOD,SeGSH-R. and CAT in rats,inhibit the formation of peroxide lipide and lipofuscin and the activity of MA.O-B,raise HDLc, lower Tc and LDLc,reduce the activity of free ribonuclease and enhance the activity of RI both in lungs and brain. Acute and chronic toxicity tests showed that this prescription was non-toxic.
出处
《湖南中医学院学报》
1991年第3期33-36,共4页
Journal of Hunan College of Traditional Chinese Medicine
关键词
抗衰延寿方
药理学
实验研究
composite (TGD)/parmacology
eucommia ulmoides/parmacology
rubus chingii/parmacology
drug screening/methods
aging/drug effects
