极后区在动脉血压对间断性冷应激反应中的作用

Role of Area Postrema in Arterial Blood Pressure Response to Intermittent Cold Stress

目的 :研究延髓极后区 (AP)在心血管对应激的反应性中的调节作用。方法 :雄性Sprague Dawley大鼠遭到极后区电损毁和间断性冷应激 ,每天跟踪其尾动脉压 (TAP)、食物和水摄入量 ,持续 2 1天。结果 :AP损毁引起食物和水摄入一过性减少 ,但不影响TAP ;应激对TAP没有显著性影响 ;但AP损毁后TAP在应激开始 5天后显著性地高于应激前和AP损毁的应激对照组以及假损毁伴应激的大鼠。结论 :AP在血压对应激的反应性中发挥了重要的调节作用 。

Objective:To investigate the role of area postrema(AP)in response of blood pressure to chronic stress.Methods:Male SD rats were subjected to AP electrolytoc lesion and/or intermittent cold stress.Water and food intake and tail arterial pressure(TAP)were daily monitored.Experiment periods were for 21 days.Results:AP lesion led to transient decreases in food and water intake,not in TAP.Cold stress did not affect TAP in AP intact rats;but could significantly increase TAP in AP lesioned rats,from fifth day after stress,as compared with before stress of after AP lesion without stress of sham with stress.Concluson:AP functions in maintenance of blood pressure homeostasis,which may not be through its regualtion in water and salt metabolism.