血清胃蛋白酶原亚群的放免测定对胃癌及其它胃部疾病的诊断意义

The Diagnostic Significance of Serum Pepsinogens PGⅠ、Ⅱ's Radioimmunoassay Applied to Detect Gastric Cancer and Other Stomach Diseases

目的 :探讨血清胃蛋白酶原亚群的放免测定对胃癌及其它胃部疾病的诊断意义。方法 :应用放射免疫分析法 ,测定消化性溃疡、胃癌和胃部其他疾病患者血清胃蛋白酶原亚群 (PGⅠ、Ⅱ )的含量及PGⅠ Ⅱ比值的变化 ,并与正常对照组比较。结果 :消化性溃疡组中以球部溃疡PGⅠ、Ⅱ数值明显上升 ;胃溃疡者也升高但与正常值重叠较多 ;胃癌组PGⅠ值明显降低以PGⅠ <35ng ml、PGⅠ Ⅱ <1.5为阳性指标 ,同时符合这两项指标的确诊率为 2 2 % ,特异性为 94% ,而将PGⅠ <35ng ml ,或PGⅠ Ⅱ <1.5为阳性指标 ,其确诊率和特异性分别为 73 % ,78%。结论 :血清胃蛋白酶原亚群数值及比值下降 ,是与胃癌发生密切相关的高危因素 ,可作为胃癌筛查的一项血清学指标 。

Objective:The diagnostic significance of serum pepsinogens PGⅠ、Ⅱ's radioimmunoassay applied to detect gastric cancer and other stomach diseases was evaluated. Methods:Radioimmunoassay was used to detect the contents and changes of the PGⅠ、Ⅱof the patients with peptic ulcer gastric cancer and other diseases of the stomach compared with those of the normal control group. Results:That the PGⅠ、Ⅱ specific value of those with Du in peptic ulcer group ascended, so did that in the gastric ulcer patients, but with more overlapping normal value. The PGⅠ、Ⅱ specific value noticeably descended in the group with gastric cancer. If PGⅠ<35ng/ml、PGⅡ< 1.5 were used as positive indexes, accurate diagnostic ratio conforming to the two indexes was 22%, and distinctive property was 94%. But if PGⅠ<35ng/ml or PGⅡ<1.5 as positive indexes, the accurate diagnostic ratio and districtive property were 73% and 78% respectively. Conclusion:The descendt of the numerical value and specific value of the serum pepsinogens Ⅰand Ⅱ is a critical factor connected closely with gastric cancer, which can be used as an serologic indication to screen gastric cancer, and which is of some clincal significance in diagnosing gastric cancer in the early stage.