诺维本治疗晚期乳腺癌临床观察

Clinical Observation of Navelbine in the Treatment of Abvanced Breast Cancer

目的 :观察诺维本 (NVB)联合阿霉素或顺铂治疗晚期乳腺癌的疗效。方法 :2 6例患者分别用NA(NVB +ADM)方案和NP(NVB +DDP)方案治疗。结果 :NA组有效率 6 6 .7% (8 12 ) ,NP组有效率 6 4.3 % (9 14 ) ,两组疗效无显著差异 (P >0 .0 5 ) ,最显著的毒性反应为骨髓抑制及静脉炎 ,NA组和NP组白细胞减少发生率分别为 75 %和 71.4% ;静脉炎的总发生率 38.5 %。其它副反应有胃肠反应、脱发及神经毒性反应。结论 :NA方案和NP方案治疗晚期乳腺癌疗效相近 。

Objectives:To evaluate the efficacy and toxicity of the compination chemotherapy with naverlbine(NVB),doxorubicin(ADM)or cisplatin(DDP)in the treatment of advanced breast cancer.Methods:Twenty six patients with advanced breast cancer were treated with combination chemotherapy naverlbine(NVB),doxorubicin(ADM)or naverlbine(NVB),cisplatin(DDP).To evaluate the therapeutic effect after two treating courses.Results:response rate were 66.7%(8/12)and 64.3%(9/14),respectively for these two groups.No statistical difference in responses was noted between these two groups( P >0.05).The main side effects were myelosuppression and phlebitis.Neutropenia occurred in 75.0% of cases in the NA groups and 71.4% in the NP groups.The phlebitis occurred in 38.5% of the total patients.No other serious side effects occurred in both groups.Conclusions:There was definitive good therapeutic effect but slightside reaction with NA group just as with NP group in the treatment of advanced breast cancer.