胰岛素抵抗与高血压脑出血的关系

The relationship between insulin resistance and hypertensive intracerebral hemorrhage

目的 研究胰岛素抵抗（IR）与高血压病脑出血之间的关系。方法 选择高血压病脑出血患者作为研究对象,测定空腹血糖（FPG）、胰岛素（FINS）、C-肽（c-p）等指标,以胰岛素敏感性指数（ISI）与对照组比较。结果FINS,c-肽和ISI均有显著性差异,ISI与FINS和c-肽呈显著负相关,c-肽与FINS存在显著正相关,与ISI呈显著负相关。结论IR是高血压病脑出血十分重要的危险因素。高胰岛素血症可以作为粗略衡量IR的指标。空腹血清c-肽水平是衡量IR更准确的指标。

Objective To study the correlation of insulin resistance(IR) with hypertensive intracerebral hemorrhage. Methods The levels of glucose, free insulin (FINS) and c-peptide (c-p) were detected in healthy controls. The patients with hypertensive intracerebral hemorrhage. The insulin sensibility index(ISI) was compared with that of the healthy controls. Results The levels of FINS,c-p and ISI in the two groups were significantly different and ISI was well correlated with FINS and c-p. c-p was positively related to FINS, and negatively related to ISI. Conclusions IR was a very important risk factor of hypertensive intracerebral hemorrhage. High INS level could be used as a index of IR, and the level of c-p could be regarde as an more accurate indicator for IR.