牙周治疗前后龈沟液中白细胞介素-6水平的变化

Interleukin-6 Levels in the Gingival Crevicular Fluid before and after Periodontal Treatment

目的 :探讨牙周洁刮治对患牙龈沟液中IL 6水平的影响。方法 :选取 12例成人牙周炎患者的重度牙周炎患牙 12颗 ,采集治疗前患牙的龈沟液并记录相关的临床指标 ,然后对患牙进行龈上洁治和龈下刮治。两周后 ,再次采集患牙的龈沟液并记录相关的临床指标。采用双抗体夹心ELISA法对牙周炎患牙龈沟液中IL 6水平进行检测 ,比较牙周洁刮治前后龈沟液中IL 6水平的差异。结果 :经过牙周洁刮治 ,患牙龈沟液中IL 6的水平明显降低 ,同时患牙的牙周临床指标也有明显的改善。结论 :牙周基础治疗在缓解牙周炎患牙局部炎症的同时 ,也对患牙局部的IL 6水平产生明显影响。

Objective:The aim of this study therefore is to determine if periodontal scaling and root planning could affect the IL-6 level in the GCF of teeth with periodontitis.Methods: 12 teeth from 12 patients with severe periodontitis were clinically examined and sampled before therapy. 2 weeks after the periodontal scaling and root planning, the same 12 teeth were examined and sampled again. The IL-6 levels in GCF were detected using ELISA method.There are some evidences that the interleukin-6 (IL-6) levels in the periodontal tissue and gingival crevicular fluid (GCF) of periodontitis sites are significantly higher than that of healthy periodontal sites. Results:The IL-6 levels in GCF from the teeth declined and the periodontal clinical indices of these teeth also apparently dropped down.Conclusion:Periodontal treatment, including periodontal scaling and root planning could affect the IL-6 levels in GCF of teeth with periodontitis.