尿视黄醇结合蛋白在诊断近端肾小管功能早期损害的价值

The Value of Retinol-binding protein of Urine in Diagnosis for early Impaired Poroximal Tubular Function

探讨尿视黄醇结合蛋白与早期近端肾小管功能损害的关系。方法:38例患者按病种分为非胰岛素依赖性糖尿病组、原发性高血压组及原发性肾脏病组,每组又按血肌酐是否正常分为二组共6组,测定各组治疗前的尿RBP平均值并与正常对照组进行对比。结果:除高血压血肌酐正常组外,其余各组尿RBP平均值均比正常对照组尿RBP平均值高,P<0.01。结论:尿视黄醇结合蛋白(RBP)可做为早期近端肾小管功能损害及早期糖尿病肾病的诊断指标。

To evaluate the relationship between Retinol-hinging protein (RBP) in urine and proximal tubular impairment. Methods 38 patients with NIDDM primary hypertension and Kidney disease were divided into six groups according to their basic disease and serun creatinine level. Uric RBP and β-MG were then detected and compared with control group. Result the mean value of uric RBP of each group was significantly increased than control group except that of hypertension with normal serum creatinine. Conclusion. Uric RBP is an index of early impairment of proximal tubu-lar function.