ANP基因Va17 Met多态性与缺血性脑卒中的关系

Relationship between Val7Met polymorphism in ANP and ischemic stroke

目的 了解心房利钠肽 (ANP)Va17Met多态性与中国人群缺血性脑卒中之间的关系。方法 我们利用PCR和分子杂交技术对该位点在北京地区缺血性脑卒中患者 (2 94人 )中的分布进行了检测和分析 ,并与非卒中人群 (2 80人 )进行比较。结果 7Met等位基因在病例组和对照组中分布频率分别为 2 5 5 %和 5 36 % ,有统计学差异 ;缺血性脑卒中患者中 7Met携带者(包括ValMet杂合子和MetMet纯合子 )比例明显低于对照组 (5 1%vs10 0 % ) ,同ValVal纯合子相比 ,7Met携带者缺血性中风的比值比为 0 484(95 %可信限 :0 2 5 6～ 0 916 ) ,特异危险性百分比和人群归因危险性百分比分别为 - 5 0 6 2 %和 - 2 5 8%。结论 提示

Objective To evaluate the relationship between the Va17Met polymorphism in atrial natriuretic polypeptide (ANP) and the ischemic stroke in Chinese population Method 294 patients with ischemic stroke and 280 controls without stroke were screened by polymerase chain reaction (PCR) and corresponding probe hybridization.Results The 7Met allele frequency was 2.55% in stroke group and 5.36%in controls.The 7Met carriers(including ValMet heterozygotes and MetMet homozygotes)proportion was also statistically different between these groups,respectively5.1%and 10.0%.The presence of 7Met allele conferred an odds ratios for stroke of 0.484(95%CI:0.256～0.916).The proportion of attributable risk(AR%)and the proportion of attributable risk of population(PAR%)were-50.62%and-2.58% respectively.Conclusions This suggests that the 7Met allele in ANP may be a protective genetic factor for ischemic stroke in Chinese population. [