慢性乙型肝炎患者血清铁、镁、铜、锌检测及相关分析

Determination of serum Fe^(3+),Mg^(2+) ,Cu^(2+),Zn^(2+) levels in patients with chronic hepatitis B and the associated statistical analysis

目的 :探讨慢性乙型肝炎 (慢乙肝 )患者血清中各年龄组Fe3 + 、Mg2 + 、Cu2 + 、Zn2 + 的含量变化。方法 :用比色法检测 12 6例慢乙肝患者及 130名健康者血清Fe3 + 、Mg2 + 、Cu2 + 、Zn2 + 。结果 :12 6例慢乙肝患者的Fe3 + 、Mg2 + 、Cu2 + 、Zn2 + 与 130名健康者的含量进行比较 ,前者的Fe3 + 、Mg2 + 、Zn2 + 显著低于后者 (P <0 .0 1) ;而前者的Cu2 + 显著高于后者 (P <0 .0 1)。根据年龄分组把 12 6例分为青、中、老三组 ,结果显示各年龄组患者的Fe3 + 、Mg2 + 和Zn2 + 含量均较对照组低 (P <0 .0 1) ,而Cu2 + 则均高于对照组 (P <0 .0 1)。结论 :检测血清Fe3 + 、Mg2 + 、Cu2 + 、Zn2 + 的含量 ,有助于慢乙肝的诊断及治疗 ,并可随时对患者进行动态的预后评价。

Objective:To observe the changes of serum Fe 3+ ,Mg 2+ ,Cu 2+ and Zn 2+ levels in patients with chronic hepatitis B.Methods:Colorimetric method was used to measure the contents of serum Fe 3+ ,Mg 2+ ,Cu 2+ and Zn 2+ in 126 patients with chronic hepatitis B and 130 healthy controls.Results:The serum levels of Fe 3+ ,Mg 2+ and Zn 2+ in patients with chronic hepatitis B were significantly lower than those in the healthy controls( P <0.01).In contrast,the serum Cu 2+ level in patients with chronic hepatitis B was significantly higher than that in the healthy controls( P <0.01).The patients were divided into young age,middle age and old age groups.The results indicate that the serum levels of Fe 3+ ,Mg 2+ and Zn 2+ in the three groups were all lower than those in the controls( P <0.01),but the serum Cu 2+ level was higher than that in the controls( P <0.01).Conclusions:Determination of serum Fe 3+ ,Mg 2+ ,Cu 2+ and Zn 2+ levels is of clinical significance in patients with chronic hepatitis B.It is also useful as a predictor of prognosis.