1[1]Moir DT, Shaw KJ, Hare RS, et al. Genomics and antimicrobial drug discovery [J]. Antimicrob Agents Chemother, 1999,43:439-446.
2[2]Mahan MJ, Tobias JW, Slauch JM, et al. Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host [J]. PNAS, 1995,92:669-673.
3[3]Akopyants NS, Frdkov A, Diatchenko L, et al. PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori [J]. PNAS, 1998,95:13108-13113.
4[4]Apfel CN, Takacs B, Fountoulakis M, et al. Use of genomics to identify bacerial undecaprenyl pyrophosphate synthetase: cloning, expression, and characterization of the essential uppS gene [J]. J Bacterial, 1999,181:483-492.
5[5]Koonin EV, Tatusov RL, Galperin MY. Beyond the complete genomes: from sequences to structure and function [J]. Curr Opin Struct Biol, 1998,8:355-363.
6[6]Huynen M, Dandekar T, Bork P. Differential genome analysis applied to the specied-specific features of Helicobacter pylori [J]. FEBS Lett, 1998,426:1-5.
7[7]Karp PD, Krummenacher M, Paley S, et al. Integrated pathway genome databases and their role in drug discovery [J]. Trends Biotechnol, 1999,17:275-281.
4Breton C,Imberty A.Structure/function studies of glycosyltransferases[J].Curr Opin Struct Biol,1999,9:563-571.
5Pouldrn SM,Kofoed C,Vester B.Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin,spiramycin and tylosin[J].J Mol Biol,2000,304:471-481.
6Walsh CT,Freel Meyers CL,Losey HC.Antibiotic glycosyltransferases:antibiotic maturation and prospects for reprogramming[J].J Med Chem,2003,46:3425-3436.
7Bertho G,Ladam P,Gharbi-Benarous J,et al.Solution conformation of methylated macrolide antibiotics roxithromycin and erythromycin using NMR and molecular modeling.Ribosome-bound conformation determined by TRNOE and formation of cytochrome P450-metabolite complex[J].Int J Biol Macromol,1998,22:103-127.
8Schlunzen F,Zarivach R,Harms J,et al.Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria[J].Nature,2001,413:814-821.
9Campbell JA,Davies GJ,Bulone V,et al.A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities[J].Biochem J,1997,326:929-942.
10Mulichak AM,Losey HC,Walsh CT,et al.Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics[J].Structure,2001,9:547-557.
