肿瘤坏死因子-α与2型糖尿病关系的探讨

Correlation between the concentration of tumor necrosis factor-alpha and type 2 diabetes mellitus

目的 探讨 2型糖尿病患者肿瘤坏死因子 α(Tumornecrosisfactor alphaTNF α)血清浓度表达。方法 测定 85例 2型糖尿病患者的血清TNF α浓度、空腹血糖、基础胰岛素水平、血三酰甘油、血高密度脂蛋白 胆固醇 (HDL C)水平和肾功能 ,并以 5 9例无糖尿病的冠心病患者作对照 ,并对相关资料作对比分析。结果 血清TNF α浓度在糖尿病组较非糖尿病组显著增高 (P <0 .0 1) ;糖尿病组中血清TNF α浓度男女性别间无差异(P >0 .0 5 ) ;与胰岛素作用指数 (IAI)相关 (r <0 .0 5 ) ;血HDL C水平与TNF α浓度负相关 (P <0 .0 5 )。结论 血清TNF α浓度过度表达可能在胰岛素抵抗和 2型糖尿病及其慢性并发症发病机制中起一定作用。

Objective To investigate teh relationship between the serum concentration of tumor necrosis factor alpha and type 2 diabetes mellitus. Methods We analyzed the serum concentration of TNF α, fasting plasma glucose(FPG), fasting plasma insulin(FINS), renal function and plasma lipids in 144 patients(59 with normal glucose tolerance and 85 type 2 diabetes mellitus). Results The serum concentration of TNF α was significantly higher in type 2 diabetics than that in patients with normal glucose tolerance( P <0.01); there was no dilfference among the male and female diabetics( P >0.05); and there was a correlation between IAI(insulin action index) and serum TNF α( P <0.05 );moreover, HDL C was inversely correlated with serum TNF α concentration. Conclusion The results suggest that increased concentration of tumor necrosis factor alpha may play a role in insulin resistance and the pathogenesis of ita comlications.