煅狗骨对实验性骨折愈合作用的甲状腺形态学研究

Thyroid Morphologic Study of Effect of Calcined dogbone on the Experimental Fracture Healing

本文运用组织学手段来检测煅狗骨对骨折愈合影响过程中甲状腺结构及功能变化。实验用家兔54只,在双侧桡骨中下1/3制成3mm缺损的骨折模型,随机分成用药组和对照组,分别喂服煅狗骨粉和生理盐水,术后定期取材,甲状腺HE染色。结果发现煅狗骨用药组并未出现对照组术后的甲状腺功能抑制状态,而表现为滤泡小、胶质少、上皮细胞高等一系列功能活跃标志,综合骨折断端组织病理学改变,作者认为煅狗骨能通过促进甲状腺功能来间接促进骨折愈合过程。

The aim of this study is to reveal the variances of thyroid morphology and function during the experiment fracture treated with calcined dogbone. 54 rabbits had been standard fractured between mid and low 1/3 of radius doubly,and were divided randomly into; (1)experimental groups which fed with powder of calcined dogbone 4g/kg/day (mixed in 20ml physiological saline ), (2 ) control groups fed with equivalent physiological saline. All animals were executed periqdically and the thyroid were dyed with histological method. The result showed that hypothyroidism happen to the control groups, but not appeared to the experimental groups. Thyroids of the experimental groups displayed reversely small follieles,less colloids and higher follicular epithelial cells which represented active thyroid functional status. So we consider that the calcined dogbone promote the fracture healing by accelerating thyroid function.