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兔桡骨缺损实验模型标准化研究 被引量：2

The Critical Size Defects as an Experimental Model in Rabbit Radius
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摘要 本实验选用新西兰成年雄性大白兔桡骨制作骨缺损模型,骨膜下桡骨切除的不同长度分别为6mm、10mm、15mm、20mm和25mm。研究结果显示,制作兔桡骨缺损模型,桡骨切除的有效长度为10mm以上,并随着桡骨切除长度的增加,骨不愈合率也随之增高。 We elected bilateral radius of 28 adult and male NZW rabbits as an experimental model of critical size defects. The length that the radius were subperiosteally removed was 6mm. 10mm. 15mm, 20mm, 25mm respectively. The results noted that the efficacious length of defective redius was more than 10mm as an experimental model of the radius,the higher it was the rate of ununions.
作者 朱建民 金宗达 陈光忠
机构地区 上海市第八人民医院 上海职工医学院
出处 《中国中医骨伤科》 1993年第4期5-7,共3页 Chinese Journal of Traditional Medical Traumatology & Orthopedics
关键词 标准尺寸 桡骨缺损 兔 动物模型 fracture bone rabbit
分类号 R683.41 [医药卫生—骨科学]
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  • 1孙新君,王正国,朱佩芳,张宇,张波,周继红,刘大维.重组人骨形态发生蛋白2/脱细胞骨基质材料复合移植修复兔骨缺损的研究[J].中华实验外科杂志,2005,22(3):287-289. 被引量：19
  • 2冯振洲,陈峥嵘,夏庆,蒋淳.骨基质明胶与羟基磷灰石修复兔桡骨缺损模型的对照研究[J].复旦学报（医学版）,2005,32(2):222-224. 被引量：4
  • 3Zhou J, Lin H, Fang T, et al. The repair of large segmental bone defects in the rabbit with vascularized tissue engineered bone. Biomaterials. 2010;31(6):1171-1179.
  • 4Bodde EW, Spauwen PH, Mikos AG, et al. Closing capacity of segmental radius defects in rabbits. J Biomed Mater Res A. 2008;85(1):206-217.
  • 5Caporali EH, Rahal SC, Morceli J, et al. Assessment of bovine biomaterials containing bone morphogenetic proteins bound to absorbable hydroxyapatite in rabbit segmental bone defects. Acta Cir Bras. 2006;21(6):366-373.
  • 6Kokubo S, Fujimoto R, Yokota S, et al. Bone regeneration by recombinant human bone morphogenetic protein-2 and a novel biodegradable carrier in a rabbit ulnar defect model. Biomaterials. 2003;24(9): 1643-1651.
  • 7EI-Ghannam A, Cunningham L Jr, Pienkowski D, et al. Bone engineering of the rabbit ulna. J Oral Maxillofac Surg. 2007; 65(8): 1495-1502.
  • 8The Ministry of Science and Technology of the People's Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006-09-30.
  • 9Hedberg EL, Kroese-Deutman HC, Shih CK, et al. Methods: A comparative analysis of radiography, microcomputed tomography, and histology for bone tissue engineering. 13ssue Eng. 2005;11(9-10):1356-1367.
  • 10Johnson EE, Urist MR, Schmalzried TP, et al. Autogeneic cancellous bone grafts in extensive segmental ulnar defects in dogs. Effects of xenogeneic bovine bone morphogenetic protein without and with interposition of soft tissues and interruption of blood supply. Clin Orthop Relat Res. 1989;(243):254-265.

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中国中医骨伤科
1993年 第4期

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