肝硬化患者检测血浆神经肽Y的临床意义

Clinical significance of determination plasma neuropeptide Y in patients with liver cirrhosis

研究肝硬化患者血浆神经肽Y的变化及其临床意义。肝硬化患者 6 4例。男 40例 ,女 2 4例 ,平均年龄 45岁± 2 3岁。其中乙型肝炎性肝硬化 5 7例 ,丙型肝炎性肝硬化 2例 ,酒精性肝硬化 4例 ,心源性肝硬化 1例 ,伴消化道出血 2 0例 ,腹水 36例 ,肝性脑病 12例和肝肾综合症 4例。按肝功能分级Child分级 :A级 2 8例 ,B级 2 3例 ,C级 13例。采用RIA法检测空腹血浆NPY水平 ,并与 40例 (男 2 6例 ,女 14例 ,平均年龄 42岁± 2 0岁 )健康人作对照。肝硬化A级患者血浆NPY含量 (12 1 6± 2 8 9) pg/ml低于健康对照组 (142 3± 40 5 ) pg/ml(P <0 0 5 )。肝硬化B级 (6 3 4± 2 4 8) pg/ml,C级 (4 5 6± 2 1 7) pg/ml患者血清NPY含量显著低于健康对照组及肝硬化A级患者 (P <0 0 1)。肝硬化患者血浆NPY含量显著低下 ,并随肝功能损害程度加重而下降更多 ,提示NPY可能参与了肝损害的病理过程 ,并与肝功能分级有关。

To study the alternation and the clinical significance of detection of plasma neuropeptide Y in patients with liver cirrhosis. Of the Patients with liver cirrosis (n=64), males 40, females 20, aged 45±23 years, 57 had hepatitis B cirrhosis, 4 alcoholic cirrhosis, 2 hepatits C cirrhosis, 1 cardiovascular cirrhosis, with GI tract bleeding 20, ascites 36, hepatic encephacopathy 12 and hepatorenal syndrome 4. According to child's classification 28 cases were in group A, 23 in group B and 13 in group C. The levels of plasma neuropeptide Y in fasting state were measured by using RIA, and 40 healthy people (n=40; 26 males, 14 femals, aged 42±20 years) were tested as controls. Plasma concentrations of neuropeptide Y in group A (121.6±28.9 pg/ml) was lower than that in healthy controls (142.3±40.5 pg/ml)(P<0.05), and group B (63.4±24.8 pg/l), group C (45.6±21.7 pg/ml) were singnificantly lower than that in healthy controls and group A (P<0.01). The levels of plasma neuropeptide Y was significantly lower in patients with liver cirrhosis, and was aggravated with the degree of injury of the liver function. It suggested that NPY may take part in the pathogenesis of the liver injury and was related with the classification of liver function.