Fas、FasL在前列腺癌表达的研究

STUDY OF Fas AND FasL EXPRESSION IN HUMAN PROSTATIC CANCER

为探讨Fas、FasL在前列腺癌发生、发展中的作用 ,应用免疫组化SP方法对 49例前列腺癌 (Pca)组织、2 2例前列腺增生症 (BPH)组织和 14例正常前列腺 (NP)组织中Fas、FasL的表达进行检测。结果表明 :①Fas、FasL表达于所有被检测的前列腺良、恶性病变及正常组织中 ;②Fas在BPH中表达强度最强 ,在Pca中表达强度最弱 (P <0 .0 5 ) ;③FasL在三组间表达强度的差异无显著性意义 (P <0 .0 5 ) ;④ 17例雄激素依赖性前列腺癌(AD Pca)组织中Fas表达强度比 9例雄激素非依赖性前列腺癌 (AI Pca)显著。由此推论Fas系统与前列腺癌发生、发展有关。

To explore the role of Fas,FasL in pathogenesis of prostatic cancer (Pca), expression of Fas and FasL in 49 cases of Pca, 22 cases of BPH and 14 cases of normal prostate(NP) was detected by immunohistochemical SP method. The results were as follows: ①Fas, FasL were expressed in all the examined tissues; ②The expression of Fas was strongest in BPH specimens and weekest in Pca tissues ( P <0 05); ③The difference of FasL expression in the three groups was not statistically significant ( P >0 05);④The expression of Fas in 17 cases of androgen dependent Pca tissues was more marked than that in 9 cases of androgen independent Pca tissues( P <0.05). The results indicate that Fas system might be related to the occurrence and progression of prostatic neoplasms.